At the Australian Open Wozniacki defeated Gisela Dulko and 21st seed Alona Bondarenko on her way to the round of 16 where Caroline Wozniacki lost to the eventual finalist and fourth-seeded Ana Ivanović. She reached the final but lost to Angelique Kerber her first loss at the tournament since the start in 2010. At the Tier III AIG Japan Open Tennis Championships Caroline Wozniacki was the top seed for the first time on the WTA Tour and Caroline Wozniacki won her third career title defeating Kaia Kanepi of Estonia in the final.
She was runner-up at the 2009 US Open and the 2010 WTA Tour Championships in Doha to Kim Clijsters. As of 23 January 2012 Caroline Wozniacki held this position for 67 weeks. She is a former World No.